USA

USMLE Step 1

600 questions

About this exam

USMLE Step 1 is the first examination in the United States Medical Licensing Examination sequence. It assesses whether medical students and graduates can apply foundational science concepts to problems relevant to patient care. Candidates commonly take it after completing much of the preclinical curriculum; U.S. and international medical students and graduates may pursue it when they meet the applicable eligibility rules. Step 1 is reported as pass or fail and is one part of the broader pathway toward medical licensure—not a medical school entrance test.

In its current format, USMLE Step 1 is a one-day, computer-based exam with seven 60-minute blocks, up to 40 questions per block, and up to 280 items in an eight-hour testing session. Questions integrate foundational sciences with clinical scenarios. Major areas include cell biology and genetics, biochemistry and metabolism, immunology, microbiology, pathology, pharmacology, and organ-system science, as well as communication, ethics, and biostatistics. For the 2027–2028 cycle, check the official USMLE materials for any format or content updates.

How to prepare for USMLE Step 1

  1. Use the current USMLE content outline to make a study plan, then prioritize weaker areas such as genetics, metabolism, immunology, and infectious diseases.
  2. Review basic science through clinical vignettes: explain why the correct answer fits and why plausible alternatives do not, rather than memorizing isolated facts.
  3. Practice timed question blocks and review your errors systematically; use the official USMLE sample questions and current exam guidance to become familiar with the format.

FAQ

Who is eligible to take USMLE Step 1?

Eligible medical students and graduates from U.S. and Canadian schools, and eligible students and graduates from international medical schools, may take Step 1 if they meet the applicable requirements. Check the current USMLE and, where relevant, ECFMG eligibility guidance before applying.

What is the format of USMLE Step 1?

Step 1 is a computer-based, multiple-choice examination delivered in timed blocks during a single testing day. The current format has seven 60-minute blocks, with up to 40 questions per block and an eight-hour testing session. Confirm current details in official USMLE materials.

What subjects should I study for USMLE Step 1?

Study foundational sciences applied to clinical problems, including cell biology and genetics, biochemistry, immunology, microbiology, pathology, pharmacology, and organ-system science. The exam also includes areas such as biostatistics, communication, and ethics; use the current USMLE content outline to guide your review.